Interventional Treatment and Molecular Imaging of Coronary and Myocardial Inflammation by Magnetic Resonance Imaging

Project Summary

This project aims to develop non-invasive magnetic resonance imaging (MRI) of inflammation with non-myocyte-specific molecular imaging contrast agents, intravascular high-resolution MRI of coronary vessel walls, and interventional real-time MRI-guided coronary intervention with implantation of scaffolds or drug eluting stents for sealing of inflamed plaques. Furthermore, P15 will characterise downstream myocardial inflammation and its heterocellular interactions after ischaemia/reperfusion, caused by catheter-based coronary artery occlusion. These tools will be used to explore temporal progression of in vivo lesion dynamics and of responses to intervention.