Cell Type-Specific Role of the Inflammasome in Myocardial Infarction

Project Summary

This project investigates mechanisms, dynamics, and consequences of inflammasome activation in different cardiac cell types during local lesion development, using a unique toolbox of transgenic models. The focus of P10 will be on two cytoplasmic sensor proteins, NLRP3 and NLRP10, with complementary expression profiles among cardiomyocytes and non-myocytes, but after myocardial infarction. Triggers, signals, and sources/recipients of mediators are explored in search of druggable targets and optimal time-windows for intervention.