This is a virtual seminar; link will be made available by email.
Immune-parenchymal partnership in the heart
It is becoming increasingly clear that immune cells are not mere defenders, but rather active elements of tissues, where they acquire specific transcriptional, epigenetic and functional properties. Here, I will discuss our recent work demonstrating the intricate partnership that macrophages and cardiomyocytes establish in the heart, and how the latter rely on macrophages for silent removal of their waste material. This partnership is ultimately important to support normal cardiac proteostasis and function. Finally, I will discuss ongoing efforts to understand how this unique relationship forms in the maturing heart and fails with age.