Pathological adaptation and plasticity in cardiomyocytes is defined by proximity to injury

Dec 14, 2020 12:00 AM

The CRC groups  Lother (P05), Fleischmann/Röll (P14), Hein (P03) and Gilsbach (P02) have recently published a collaborative study:

The adult mammalian heart consists of mononuclear and binuclear cardiomyocytes (CM) with various ploidies. However, it remains unclear whether a variation in ploidy or number of nuclei is associated with distinct functions and injury responses in CM, including regeneration. Here we show, that proximity to injury, but neither number of nuclei nor ploidy define pathological adaptation and plasticity in cardiomyocytes. [direct link to article]